Structural Basis for Fas-Mediated Apoptosis and Mechanism of Inhibition
Friday, November 7, 2014
Plaza Foyer (Sheraton)
This is a structural, biochemical study of Fas interactions with Calmodulin. We have identified a specific binding stoichiometry, binding parameters, and the amino acids comprising the minimal binding domains. This will lead to the development of effective yet minimally toxic drugs to target diseases that involve an abnormal cell count.