Synthesis of Indole-2-Carboxylic Acid Derivatives as Antagonists of Mutant BRAF Receptors in Melanoma

Melanoma can occur due to a mutated receptor in the Mitogen-activated Protein kinase pathway. To inhibit the resulting uncontrolled cell growth, a novel ligand must be developed. A virtual library was designed and tested for theoretical potency. The most promising molecules were synthesized and tested for actual potency on the BRAF receptor.