Synthesis of Indole-2-Carboxylic Acid Derivatives as Antagonists of Mutant BRAF Receptors in Melanoma

Friday, November 7, 2014
Plaza Foyer (Sheraton)
Jeremiah Atkinson , South Dakota State University
Lauren Kuschel , South Dakota State University
Melanoma can occur due to a mutated receptor in the Mitogen-activated Protein kinase pathway. To inhibit the resulting uncontrolled cell growth, a novel ligand must be developed. A virtual library was designed and tested for theoretical potency. The most promising molecules were synthesized and tested for actual potency on the BRAF receptor.