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Inhibition of CYS2HIS2 Zinc Finger Proteins with Co(III) Complexes
Inhibition of CYS2HIS2 Zinc Finger Proteins with Co(III) Complexes
Friday, November 8, 2013: 11:00 AM - 1:00 PM
Napoleon B3-C3 (Sheraton New Orleans Hotel)
Our study investigates the potential therapeutic effects of Cobalt(III) Schiff Base complexes. The specific reaction mechanism we are studying is the exchange of one axial ligand of [Co(III)(acacen)(NH3)2]Cl with an active-site histidine residue found in zinc finger transcriptional factors, which bind to cancerous DNA, thus inhibiting the protein's enzymatic function.
