Increasing Protein O-GlcNAc Modification: A New Therapeutic Strategy for TBI

Modification of proteins by the O-linked attachment of ��-N-acetyl-glucosamine (O-GlcNAc) causes reduction of cellular damage after traumatic brain injury (TBI). To test the hypothesis that increasing cellular O-GlcNAc will increase neuronal survival after TBI, the effect of thiamet-G, an inhibitor of O-GlcNAcase was assessed.