Effect of O-Glcnac Modification

Modification of proteins by ß-N-acetyl-glucosamine (O-GlcNAc) has been shown to play a critical role in regulation of cellular survival. One mechanism for increasing O-GlcNAcylation is pharmacological inhibition of OGA (O-GlcNAcase). We will study the functional and biochemical effects of O-GlcNAc modulation via thiamet-G in rodent models.