Endogenous Kappa Opioid Receptors Play a Role in Angiotensin II High-Salt Diet Hypertensive Rats

Central kappa-opioid receptor (KOR) activation produces marked increase in renal sympathetic nerve activity with concurrent free water diuresis in conscious rats. Furthermore, activation of opioid receptors has been shown to modulate blood pressure. However, the role of KOR in angiotensinII high-salt diet (AngII) mediated hypertension model is to be determined.