Synthesis of a New Series of 2-Acetyl-4-Methylthiazole Thiosemicarbazone Compounds: NMR and MIC Studies

Friday, November 7, 2014
Plaza Foyer (Sheraton)
Alexandra Arriaga , Tennessee Technological University
Thiosemicarbazone compounds are a class of multidentate ligands that contain binding sites for metal ions such as iron and copper. This work will present the synthesis of 2-acetyl-4-methylthiazole thiosemicarbazone compounds: These are potential anti-cancer agents because they interfere with ribonucleotide reductase, an iron-containing enzyme used by cells to produce DNA.